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December 1991

Frontal Lobe Dysfunction Following Infarction of the Left-Sided Medial Thalamus

Author Affiliations

From the Behavioral Neurology Unit (Drs Sandson, Daffner, and Mesulam), Beth Israel Hospital, and the Department of Radiology, Brigham and Women's Hospital (Dr Carvalho), Boston, Mass.

Arch Neurol. 1991;48(12):1300-1303. doi:10.1001/archneur.1991.00530240106031

• We treated a 62-year-old woman who developed a dramatic change in personality and behavior following a discrete left-sided medial thalamic infarction involving the dorsomedial nucleus. Neuropsychological testing demonstrated severe impairment of complex executive behaviors that are usually associated with frontal lobe function. Electroencephalography and single-photon emission computed tomography strongly implicated dysfunction of the ipsilateral frontal lobe. This case further supports a functional and physiologic thalamofrontal linkage as part of a broader cerebral network modulating complex human behavior.