• We treated a 62-year-old woman who developed a dramatic change in personality and behavior following a discrete left-sided medial thalamic infarction involving the dorsomedial nucleus. Neuropsychological testing demonstrated severe impairment of complex executive behaviors that are usually associated with frontal lobe function. Electroencephalography and single-photon emission computed tomography strongly implicated dysfunction of the ipsilateral frontal lobe. This case further supports a functional and physiologic thalamofrontal linkage as part of a broader cerebral network modulating complex human behavior.
Thomas A. Sandson, Kirk R. Daffner, Paulo A. Carvalho, M-Marsel Mesulam. Frontal Lobe Dysfunction Following Infarction of the Left-Sided Medial Thalamus. Arch Neurol. 1991;48(12):1300–1303. doi:10.1001/archneur.1991.00530240106031