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January 1992

Increased Adherence of T Cells to Human Endothelial Cells in Patients With Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy

Author Affiliations

From the First Department of Internal Medicine (Drs Ichinose, Nakamura, Kawakami, Eguchi, Nagasato, Shibayama, and Nagataki), Nagasaki (Japan) University School of Medicine, and School of Allied Medical Sciences (Dr Tsujihata), Nagasaki University.

Arch Neurol. 1992;49(1):74-76. doi:10.1001/archneur.1992.00530250078019

• We investigated the adherence of T cells to human umbilical vein endothelial cells in seven patients with human T-lymphotropic virus type I (HTLV-I)—associated myelopathy. The adherence of T cells to endothelial cells increased significantly in all the patients with HTLV-I—associated myelopathy when compared with the adherence in the seronegative controls (1.3-to 2.8-fold) and compared with the adherence in the anti—HTLV-I—seropositive non—HTLV-I—associated myelopathy carriers (1.4- to 2.8-fold). Prior treatment of the endothelial cell monolayer with recombinant interferon gamma (50 IU/mL) enhanced the T cell—endothelial cell adhesion in both the controls and patients with HTLV-I—associated myelopathy. However, values after prior treatment in the patients with HTLV-I—associated myelopathy were significantly higher than those in seronegative controls and carriers. The results suggest that the significantly increased T cell—endothelial cell adherence may be related to the initial stages of lymphocyte migration from the blood to the central nervous system in patients with HTLV-I—associated myelopathy.

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