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April 1992

Cerebral Sinus Thrombosis: Experimental and Clinical Aspects

Arch Neurol. 1992;49(4):342. doi:10.1001/archneur.1992.00530280020006

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Cerebral Sinus Thrombosis is the result of a 1987 symposium on cerebral venous thrombosis (CVT). (Note that this book's editors prefer the term "cerebral sinus vein thrombosis.") Cerebral Sinus Thrombosis is presented in three parts: "Structural and Functional Basis," "Mechanism of Brain Tissue Damage," and "Clinical Aspects of Sinus Vein Thrombosis." The first part reviews the morphologic appearance of the venous system as it concerns the dura, describes the neuropathologic findings associated with cerebral venous thrombosis, and discusses experimental models of cerebral venous sinus thrombosis. The article on the beneficial effects of heparin in experimental CVT will be of particular interest to clinicians. The section on the mechanisms of braintissue damage in CVT contains articles on the physiology and pathophysiology of the cerebral venous circulation, the effect of hypoxia on smooth-muscle cells, the mechanism of ischemic brain damage, and the effects of eicosanoids, peptides, and amines on cerebral circulation. Recent

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