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June 1992

Subacute Idiopathic Demyelinating Polyradiculoneuropathy

Author Affiliations

From the Department of Neurology (Drs Hughes, Sanders, Colchester, and Payan and Ms Atkinson) and the Division of Anatomy and Cell Biology (Dr Hall), United Medical and Dental Schools, Guy's Hospital, London, United Kingdom, and the Department of Neurology, Ignatius Hospital, Breda, the Netherlands (Dr Sanders).

Arch Neurol. 1992;49(6):612-616. doi:10.1001/archneur.1992.00530300044009

• Seven cases of subacute idiopathic demyelinating polyradiculoneuropathy had a monophasic illness characterized by progressive weakness of all four limbs that evolved during 4 to 8 weeks. Neurophysiological investigations implied demyelination in all seven cases. In two patients, sural nerve biopsy specimens that were taken showed macrophage-associated demyelination. All patients made substantial or complete recoveries with oral prednisolone (four cases) or without treatment (three cases). None of the patients required ventilation or had autonomic complications. These cases provide a link between the acute idiopathic demyelinating form of Guillain-Barré syndrome and chronic idiopathic demyelinating polyradiculoneuropathy.

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