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October 1992

Neurotransmitters and Epilepsy

Author Affiliations

Washington, DC

Arch Neurol. 1992;49(10):1005. doi:10.1001/archneur.1992.00530340019005

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Neurotransmitters and Epilepsy provides an overview of the research issues posed by the clinical state of epilepsy with respect to what is known about the function of neurotransmitters. The book is the product of collaborative work by many authors, many of whom are members of the faculty of the School of Medicine of The Johns Hopkins University, Baltimore, Md.

The book starts slowly with a clinical overview of epilepsy and a discussion of the mechanisms of neurotransmitter receptor actions. This includes a brief summary of the technique of patch clamping, receptor subtypes, and second messengers. The latter is discussed in several chapters. Models of epilepsy in animals are discussed; a series of chapters follow on specific neurotransmitters in relation to seizure phenomena: GABA (Ψ-aminobutyric acid), acetylcholine, serotonin, norepinephrine, glutamate, and NMDA (N-methyl-dasparate) receptors. There are also chapters on opioids and extracellular amino acids with respect

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