• A questionnaire concerning the occurrence of Parkinson's disease in parents was administered for 252 patients with Parkinson's disease. Eleven fathers and five mothers of patients were reported to also have had this disease. These data fail to provide support for the hypothesis that Parkinson's disease is the result of maternal inheritance of an abnormal mitochondrial gene. This conclusion is further supported by a review of similar studies in the literature and an additional unpublished study, which revealed that of 922 patients with this disease, 37 fathers and 19 mothers were reportedly affected.
Zweig RM, Singh A, Cardillo JE, Langston JW. The Familial Occurrence of Parkinson's Disease Lack of Evidence for Maternal Inheritance. Arch Neurol. 1992;49(11):1205–1207. doi:10.1001/archneur.1992.00530350127029
Neurology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.