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December 1992

The Neuropsychology of the Cerebellum: An Emerging Concept

Author Affiliations

Neurology Service Hotel-Dieu Hospital 3840 St Urbain St Montreal, Quebec Canada H2W 1T8

Arch Neurol. 1992;49(12):1229-1230. doi:10.1001/archneur.1992.00530360027009

To the Editor.  —I read with utmost interest Schmahmann's article1 on the cerebellar contribution to higher function. This article, however, seems to be incomplete. The association between cerebellar damage and mental or neuropsychologic disorders has sometimes been mentioned in the literature, but no firm clinical and physiopathologic (cause-effect) relationships were documented in neurologic patients before our article2 was published in 1985, in which we emphasized the role of cerebellofrontal and cerebelloparietal pathways as anatomic substrata of the mild frontal and parietal-like syndrome encountered in our patients. After publication of this article,2 our laboratory undertook to answer the following questions: (1) Which are the specific (if indeed they are) neuropsychologic disorders associated with well-delimited bilateral cerebellar damage (BCD) vs those found in patients with unilateral cerebellar damage (UCD)2; (2) Which are the anatomic, metabolic, or neurochemical substrata subserving these disorders?; (3) Will neurobehavioral studies on mutant mice

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