To the Editor.
—Bilateral and symmetric periventricular white-matter lucencies observed by computed tomographic (CT) scanning, so-called leuko-araiosis (LA), are commonly seen in elderly subjects. The same type of lesions have been encountered in non-demented and demented patients with or without cerebrovascular disease.1 The CT findings of the deep white matter, when symptomatic, are characterized by subcortical and cortical dementia, urinary incontinence, acute and subacute motor deficits, presence of primitive reflexes, and abnormal gait, and they have a subacute progression with long plateau periods. Leuko-araiosis has been associated with aging, lacunar infarcts, and hemorrhages seen on CT scans, a history of stroke, and disordered blood pressure regulation.2,3 We describe herein the relationship between LA and hypertension found in a prospective study carried out from June 1985 through April 1991 in a hospital for elderly people.The patients studied, all of whom were of Caucasian origin, over 50 years old,
Dominguez R, Famulari A, Garcia G, et al. Early Onset of Leuko-araiosis in Hypertensive Patients. Arch Neurol. 1993;50(1):13–14. doi:10.1001/archneur.1993.00540010009006
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