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April 1993

Immunoglobulin G Immunosuppression of Multiple Sclerosis: Suppression of All Three Major Lymphocyte Subsets

Author Affiliations

From the Division of Neurology, Penn State University College of Medicine, Hershey, Pa. Dr Aberg is now with the Cleveland (Ohio) Clinic Foundation.

Arch Neurol. 1993;50(4):417-420. doi:10.1001/archneur.1993.00540040069017

• Six patients with relapsing chronic progressive multiple sclerosis were treated on 2 consecutive days with large amounts of IgG to induce immunosuppression. Peripheral blood lymphocyte subsets were monitored for 5 weeks after IgG treatment to determine immunosuppression. Decreased numbers of B, T, and natural killer lymphocytes were detected after treatment. Lymphocyte numbers were at a nadir 1 week after treatment, but an immunosuppressive effect continued to be present after 5 weeks. Although clinical efficacy was not evident in this brief open trial, the decrease of peripheral lymphocyte numbers and the apparent safety of the procedure warrant further study.

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