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May 1993

Headache and Depression: Serotonin Pathways as a Common Clue

Author Affiliations

Kansas City, Kan

Arch Neurol. 1993;50(5):449. doi:10.1001/archneur.1993.00540050005002

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This book is a collection of 30 chapters of widely varying subject matter—the unifying theme being that these chapters deal with depression, headache, or both. Sections include the following: neurochemistry of 5-hydroxytryptamine pathways, with four excellent chapters on this subject and review of findings as they relate to headache, depression, and pain; chronic headache and mood disorders, four primarily clinical chapters with a brief, interesting review of pain threshold studies; periodicity of affective and headache disorders, with chapters on seasonal cycles found in depression, menstrual cycles in mood and headache, and effects of different treatments; drugs affecting the serotonergic system (seven chapters of widely varying quality) with three review articles, one (by Sicuteri) giving a summary of his overall formulation of central pain systems, another summarizing data on serotonin and depression, and three subsequent studies briefly reporting results on specific pharmacologic agents; and miscellaneous communications on clinical subjects in the

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