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May 1993

Long-term Potentiation

Author Affiliations

Chicago, Ill

Arch Neurol. 1993;50(5):449-450. doi:10.1001/archneur.1993.00540050005004

This is a very good book. Probably, it should be considered essential to the library of all those interested in the fundamental mechanisms of neuronal plasticity. One possible explanation for the quality of the book is that the editors, Michael Baudry and Joel Davis, demanded of the participants that they center their discussion around controversial issues in the field of long-term potentiation. Each author was asked to not simply present his or her own data and theoretical position but also to constructively criticize the alternative views. The result was an unusually vigorous and challenging presentation from each of the leading researchers in the field.

Long-term potentiation (LTP) (for those readers unfamiliar with the process) refers to the observation that repetitive activation of certain types of excitatory synapses results in a long-lasting enhancement of transmission through those synapses. This activity-dependent modulation of synaptic function is considered perhaps the leading experimental model

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