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June 1993

Monitoring Neuronal Activity: A Practical Approach

Author Affiliations

Rochester, NY

Arch Neurol. 1993;50(6):566. doi:10.1001/archneur.1993.00540060008004

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


More than 200 years ago, the Earl of Chesterfield warned: "Advice is seldom welcome; and those who want it the most always like it the least." But this may not apply to those seeking advice on monitoring neuronal activity. There is much to like in this comprehensive coverage of techniques for detecting the electrical, ionic, chemical, and metabolic changes associated with nerve cell activity. The topics include extracellular recording of electrical (action potential) activity, microelectrode and patch clamps, optical and electrical methods of determining ion concentrations, and methods for detecting transmitter release.

The book is well organized, and the table of contents includes a detailed list of the topics for each chapter. This and the comprehensive index greatly facilitate the search for specific information. This is important, since most users of the book are likely to be interested in only a small subset of topics. Every chapter contains several illustrations.

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