• Myasthenic crisis is a potentially life-threatening complication of myasthenia gravis that requires aggressive therapy. We describe four patients in whom myasthenic crisis developed and who failed to respond to initial treatment with intravenous γ-globulin. All four patients subsequently responded to intensive plasma exchange. Based on our experience, plasmapheresis appears to be superior to intravenous γ-globulin for the treatment of myasthenic crisis in certain patients. Prognostic factors that determine the effectiveness of intravenous γ-globulin vs plasmapheresis in these patients merit further investigation.
Stricker RB, Kwiatkowska BJ, Habis JA, Kiprov DD. Myasthenic Crisis: Response to Plasmapheresis Following Failure of Intravenous γ-Globulin. Arch Neurol. 1993;50(8):837–840. doi:10.1001/archneur.1993.00540080046012
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