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September 1993

Landau-Kleffner Syndrome: Some Suggestions

Author Affiliations

Department of Child Neuropsychiatry Gaslini Institute Genoa University 16148 Genoa, Italy

Arch Neurol. 1993;50(9):896. doi:10.1001/archneur.1993.00540090007001

To the Editor.  —In the April 1992 issue of the Archives, the Landau-Kleffner syndrome was considered in an editorial by Landau1 and in an article by Paquier et al.2Landau in particular revisited some of the fundamental questions underlying this condition, ie, its etiopathogenesis, the relationship between paroxysmal activity and language troubles, the course of the illness, and its response to antiepileptic treatment.In an article published in 1980,3 based on personal experience and on the analysis of cases published to that date, the attempt was made to provide an answer to these same questions, suggesting that a strict causal connection between paroxysmal activity and language function disorder could be presumed, if the following were taken into account: (1) the characteristics of the diffuse continuous paroxysmal electroencephalographic activity typical of the developmental age, giving risk to partially reversible functional neuropsychic destructuring, and responsive only to certain types

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