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October 1993

What Differentiates Landau-Kleffner Syndrome From the Syndrome of Continuous Spikes and Waves During Slow Sleep?-Reply

Author Affiliations

Division of Neurolinguistics Antwerp University Hospital Wilrijkstraat 10 2650 Edegem Belgium
Department of Neurology Academic Hospital of Rotterdam 40 Dr Molewaterplein 3015 GD Rotterdam the Netherlands

Arch Neurol. 1993;50(10):1009. doi:10.1001/archneur.1993.00540100009007

In Reply.  —We appreciate the interest in our article shown by Genton and Guerrini, and welcome their excellent completion concerning the phenomenon of electrical status epilepticus during slow sleep.1Their recent study2 provides important information that might help in outlining the possible boundaries between the Landau-Kleffner syndrome and the syndrome of electrical status epilepticus during slow sleep. Indeed, several authors3-6 have recently expressed the view that a sharp demarcation between both entities is not warranted and that both syndromes apparently reflect different aspects of a similar underlying, still unexplained, cerebral dysfunction. We feel that full-night polysomnographic studies, if possible in combination with information from studies on cerebral glucose metabolism7 or regional cerebral perfusion,8 might shed new light on the basic pathophysiologic cause of both conditions.Anyhow, we wish to emphasize the opinion of Genton and Guerrini that at least one full sleep cycle recording, including