• We report the first case of nonconvulsive status epilepticus as a complication of chemotherapy with the nitrogen mustard derivative ifosfamide. Our patient developed encephalopathy, upper extremity myoclonus, and a periodic, triphasic electroencephalogic pattern that resolved acutely with intravenous diazepam treatment. Since significant morbidity and mortality is associated with unrecognized status epilepticus, electroencephalogic monitoring and a trial of diazepam is indicated in encephalopathic patients with rhythmic electroencephalogic patterns while receiving treatment with ifosfamide.
William J. Wengs, Dinesh Talwar, Jacqueline Bernard. Ifosfamide-Induced Nonconvulsive Status Epilepticus. Arch Neurol. 1993;50(10):1104–1105. doi:10.1001/archneur.1993.00540100089024