This Issue of the Archives is devoted to recent achievements in neurogenetics. The past decade has truly been a remarkable time of advancement in this field, and this issue captures some of the excitement and momentum. Leading authorities have been selected to review the current molecular basis of Alzheimer's disease (AD), Huntington's disease (HD), mitochondrial encephalomyopathies, prion diseases, Charcot-Marie-Tooth syndrome, neurofibromatosis, myotonic dystrophy, Duchenne-Becker muscular dystrophy (DMD), Gaucher disease, skeletal muscle sodium-channel diseases, and potential areas of treatment, including gene therapy. The result, in my view, is a superb exposition of the vitality and progress of investigation in understanding these important inherited neurological diseases at the molecular level. A neurological gene map has been included as well, describing the positional chromosome location for each disease as determined by linkage analysis.1-3I shall briefly comment editorially on the progress made in several of these diseases and leave the major discussion