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February 1994

The Molecular and Genetic Basis of Neurological Disease

Author Affiliations

Rochester, NY

Arch Neurol. 1994;51(2):114. doi:10.1001/archneur.1994.00540140016003

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This volume is edited by five international authorities on the molecular biology of neurologic disease and includes chapters by many of the neuroscientists who have made major contributions to the field. A majority of the authors are clinicians, which make most chapters readable and useful for the neurologist. The 66 chapters begin with five introductory chapters that review general concepts of genetics with specific reference to neurologic diseases. Fifty subsequent chapters address specific diseases or groups of diseases. The final two chapters consider the prospects of gene therapy and the importance of the Human Genome Project for neurologic disease. Each chapter begins with a useful abstract, and each diseasefocused chapter begins with a clinical discussion. The various chapters by the five editors are particularly strong, representing summaries of their seminal contributions.

The book cannot be viewed as a textbook, since some important neurologic diseases with a genetic basis or genetic

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