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March 1994

Subacute Inflammatory Demyelinating Polyneuropathy: Not a New Concept

Author Affiliations

Department of Neurology University of Alabama at Birmingham Birmingham, AL 35294

Arch Neurol. 1994;51(3):234-235. doi:10.1001/archneur.1994.00540150020008

Hughes et al1 described seven cases of subacute "idiopathic" demyelinating polyradiculopathy (SIDP) characterized by progressive weakness of all four limbs over 4 to 8 weeks, high spinal fluid protein in a majority of cases, good response to steroids in four of seven cases, and monophasic illness.1 They proposed that this disorder provides a link between the Guillain-Barré syndrome and chronic idiopathic demyelinating polyradiculoneuropathy (CIDP).

Their concept is not new. In fact, I proposed this concept in 1978 in an article published in the Archives2 and en

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