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July 1994

Cerebral Dysgenesis

Author Affiliations

Rochester, NY

Arch Neurol. 1994;51(7):642. doi:10.1001/archneur.1994.00540190016004

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Modern neuroimaging with magnetic resonance, computed tomography, and ultrasound now allows us to view the nervous system in the living subject in remarkable detail. These techniques have been especially helpful in studying the broad spectrum of central nervous system anomalies that occur during development. A variety of diagnoses that were once difficult to make, such as lissencephaly, pachygyria, and delayed myelination, can now be confirmed during life. However, understanding the embryologic basis of these disorders and putting them in a meaningful context for the medical practitioner is a formidable task. This is what Dr Sarnat undertakes and, indeed, achieves.

This is a single-author text, but he acknowledges assistance from colleagues around the world and from many subspecialties. Only an individual with a broad knowledge of neurodevelopment from multiple perspectives could hope to achieve this goal. Fortunately, Dr Sarnat is just such a scholar. His writings and research have spanned clinical

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