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July 1994

Depression in Neurologic Disease

Author Affiliations

Rochester, NY

Arch Neurol. 1994;51(7):643. doi:10.1001/archneur.1994.00540190017006

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We have come a long way in our understanding of depression since Freud's publication in 1917 of Mourning and Melancholia. In that work and in others early in this century, we felt the power of psychological explanations for depression. Now we are beginning to explore competing neuroscientific explanations for depressive disorders. In Depression in Neurologic Disease, Drs Starkstein and Robinson provide an edited review of lessons in the neuropsychiatry of depression that have come from clinical neurology.

All neurologists know that patients with certain neurologic diseases are more likely to become depressed than patients with others. Stroke is the example that the editors of this book have studied most carefully. They noticed early that right-handed patients with anterior left hemisphere lesions were more likely to become depressed during the immediate time period after stroke than were patients with stroke in other areas. This anatomic association of lesion location with depressive

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