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July 1994

Similar Postictal Serum Prolactin Response in Complex Partial Seizures of Temporal or Frontal Lobe Onset

Author Affiliations

Department of Epileptology
Department of Clinical Biochemistry University of Bonn Sigmund-Freud-strasse 25 53105 Bonn, Germany

Arch Neurol. 1994;51(7):645. doi:10.1001/archneur.1994.00540190019009

In 1992, Meierkord and coworkers1 published their findings on postictal serum prolactin response in patients with complex partial seizures (CPS). A rise in the serum PRL level was detected following six of eight CPS of temporal lobe origin and one of eight CPS with frontal lobe onset. From these findings, the authors concluded that the measurement of the postictal serum prolactin level might help to differentiate between CPS of temporal and frontal lobe onset. However, our study in 80 patients with CPS did not support this hypothesis.

All patients investigated were monitored during presurgical evaluation. Seizures were classified by simultaneous video-electroencephalogram monitoring with the use of subdural intracranial electrodes. The patients were divided into two groups: 60 patients (27 male and 33 female, aged 18 to 52 years) with CPS of temporal lobe onset and 20 patients (13 male and seven female, aged 19 to 42 years) with CPS