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August 1994

The Effect of Carbamazepine on Serum Lipid Levels-Reply

Arch Neurol. 1994;51(8):749. doi:10.1001/archneur.1994.00540200022008

In reply  We thank Wagner and Preblick for their interest in our study1 regarding serum lipid levels during carbamazepine medication. They present some criticisms on the statistical methods that we used. However, we feel that the statistical analysis with the paired t test was adequate and did not increase the chance of finding significant differences when they were not present.We have reanalyzed the data with analysis of variance (ANOVA) for repeated measures with a post-hoc test (Fisher's LSD test). All differences that were significant with the paired t test remained significant with the new analysis. Actually, serum high-density lipoprotein cholesterol levels after 2 months (P<.001) and low-density lipoprotein cholesterol levels after 12 months (P<.001) differed more significantly from the premedication values with the new analysis than with the paired t test used in the original analysis of the data.1 Therefore, the conclusions presented in our article were