We were gratified to read the letter by DeCarli et al, concerning their study of volumetric measures on magnetic resonance imaging (MRI) in patients with probable Alzheimer's disease (AD).1 We agree that the use of a discriminant function analysis is a powerful and important tool for dissociating meaningful, reliable changes early in the course of AD from those associated with successful, normal aging. We are delighted to learn of this independent confirmation of our findings2,3 and look forward to the full-length publication of data from DeCarli et al.In their work,1,4,5 DeCarli et al have suggested age and gender to be important variables for dissociating AD from normal aging. Clearly, age is a risk factor in AD but, to date, data suggesting gender as a discriminating variable in AD are equivocal. In our work, we have used control subjects from the same age cohort as
Killiany RJ, Moss MB, Albert MS. Discriminant Analysis of Alzheimer's Disease-Reply. Arch Neurol. 1994;51(11):1088–1089. doi:10.1001/archneur.1994.00540230026007
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