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January 1995

Alzheimer's Disease Presenting as Slowly Progressive Aphasia and Slowly Progressive Visual Agnosia: Two Early Reports

Author Affiliations

Department of Neurology University of Essen Hufelandstrasse 55 45122 Essen, Germany

Arch Neurol. 1995;52(1):10. doi:10.1001/archneur.1995.00540250012002

Luzatti and Poeck, in the February 1991 issue of the Archives, presented "An Early Description of Slowly Progressive Aphasia"1 that had been published in 1907 by Max Rosenfeld. They intended to demonstrate that the problem of focal atrophy of the brain with the clinical manifestation of an isolated progressive neuropsychological deficit had already been recognized at the beginning of this century. I would like to add another historical case with similar clinical and neuroanatomical features. It was described by the German neurologist Hans Gerhard Creutzfeldt (1885-1964) in 1921 who was then a lecturer in Kiel, Germany.2

Creutzfeldt reported on a 60-year-old patient with a 5-year history of slowly progressive aphasia. The disorder started at the age of 55 years with word-finding difficulties. It developed through a stage with features of amnestic aphasia and Wernicke's aphasia toward a terminal stage of global aphasia. Accompanying neuropsychological deficits, particularly symptoms of

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