To study brain histologic features in two cases of idiopathic intracranial hypertension (pseudotumor cerebri) at autopsy.
Formaldehyde solution—fixed sections of cerebral white matter in two cases and structures of the sensory visual system in one case were analyzed.
University medical center.
Two patients with idiopathic intracranial hypertension who died unexpectedly.
Main Outcome Measure:
Histologic study of cerebral white matter in the two patients.
We did not find histologic evidence of any type of cerebral edema in our patients. Review of a portion of the material from a previous report is also consistent with this conclusion.
If patients with idiopathic intracranial hypertension have histologically apparent cerebral edema, it is not a consistent finding.
Wall M, Dollar JD, Sadun AA, Kardon R. Idiopathic Intracranial Hypertension: Lack of Histologic Evidence for Cerebral Edema. Arch Neurol. 1995;52(2):141–145. doi:10.1001/archneur.1995.00540260045014
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