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May 1995

Dopamine D2 Receptor and Tourette's Syndrome

Author Affiliations

Department of Medical Genetics National Medical Center, National Medical Center, 1500 F Duarte Rd, Duarte, CA 91010-0269

Arch Neurol. 1995;52(5):441-442. doi:10.1001/archneur.1995.00540290019004

I was pleased to see the study by Gelernter et al1 concerning the role of the dopamine D2 receptor (DRD2) gene in Tourette syndrome (TS) because the authors so nicely verified our previous studies demonstrating a role the DRD2 gene in TS and because they illustrated some of the issues concerning association vs linkage studies in neuropsychiatric disorders. I felt that it was necessary to write this letter because the way in which the results were reported may have left the wrong impression with readers who are not familiar with the field.

In 1991, we2 reported that the prevalence (percent with the 11 or 12 genotype) of the D2A1 allele in 147 non-Hispanic white TS probands was 44.9%. This was significantly greater than the prevalence of 24.5% in 314 non-Hispanic white control subjects (P =.0001). Subsequently, we3 reported on an enlarged set of 220

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