To report the clinical and immunological response to immunosuppressive treatment with cyclophosphamide in two patients with paraneoplastic cerebellar degeneration.
Case reports. Clinical and immunological follow-up data were available for 4½ years in the first patient and for 2 years in the second patient.
A 1500-bed university hospital and a 1200-bed university teaching hospital.
Cyclophosphamide intermittent treatment.
Main Outcome Measure:
One of the patients, who was treated from an early stage, recovered completely. The other patient showed a partial clinical response. While the two patients were receiving a maintenance regimen with cyclophosphamide, the conditions of both patients remained stable for at least 2 years. In both patients, intrathecal antibody synthesis declined considerably.
Early induction of immunosuppressive therapy with cyclophosphamide should be tried in treating patients with paraneoplastic cerebellar degeneration.
Stark E, Wurster U, Patzold U, Sailer M, Haas J. Immunological and Clinical Response to Immunosuppressive Treatment in Paraneoplastic Cerebellar Degeneration. Arch Neurol. 1995;52(8):814–818. doi:10.1001/archneur.1995.00540320098016
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: