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September 1995

P300 and Xenon Computed Tomography Before and After Intravenous Injection of Acetazolamide

Author Affiliations

Department of Neurology Nihon University School of Medicine Tokyo 173, Japan

Arch Neurol. 1995;52(9):850-851. doi:10.1001/archneur.1995.00540330020005

Acetazolamide, which is a carbonic anhydrase inhibitor, is thought to dilate cerebral blood vessels by increasing the carbon dioxide level.1-4 To investigate the dilatory reserve of the cerebral blood vessels, cerebral blood flows are measured before and after intravenous injection of acetazolamide. There are no reports on the influence of acetazolamide on P300. We measured cerebral blood flow and P300 before and after intravenous injection of acetazolamide in healthy subjects and patients with cerebral infarction.

Ten healthy subjects (mean age, 54 years) and 20 patients with cerebral infarction (mean age, 56 years) were studied with their informed consent. We selected the patients in whom the size of the cerebral infarction was between 5 and 20 mm in longer diameter. We excluded the patients who could not count the numbers. The period of examination was within 2 weeks from the onset of cerebral infarction. All patients with cerebral infarction were

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