We investigated the use of immunostaining with antibodies to τ, ubiquitin, and αB-crystallin in defining a protocol for the staged neuropathologic examination of brains from patients with a progressive frontotemporal dementia.
Brains obtained from 50 patients dying with the clinical diagnosis of frontotemporal dementia were examined histopathologically to define pathologic distinctions.
Two university hospital neuropathology departments.
Anti-τ immunostaining defined corticobasal degeneration, Alzheimer's disease, and Pick's disease; antiubiquitin defined motor neuron disease with dementia. The remaining brains have frontal lobe degeneration: the use of αB-crystallin immunostaining, on these, to detect ballooned neurons may help to define two groups of patients, one of which we believe may represent a variant of Pick's disease.
These findings indicate that immunostaining with these antibodies is essential for the evaluation of frontal dementia.
Cooper PN, Jackson M, Lennox G, Lowe J, Mann DMA. τ Ubiquitin, and αB-Crystallin Immunohistochemistry Define the Principal Causes of Degenerative Frontotemporal Dementia. Arch Neurol. 1995;52(10):1011–1015. doi:10.1001/archneur.1995.00540340103019
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