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December 1995

Toxin-Induced Models of Neurological Disorders

Author Affiliations

Portland, Ore

Arch Neurol. 1995;52(12):1139-1140. doi:10.1001/archneur.1995.00540360017006

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This collection of articles on toxin-induced models of neurological disorders contains a number of very good reviews but has a more limited scope than the title would suggest. The introductory chapter contains an excellent discussion of the ethics of and the rationale for animal research, followed by a discussion of the validity and limitations of animal models. This is followed by a chapter on strategies for developing neurotoxicant-induced animal models of neurodegenerative disorders. Chapters on motor neuron degeneration, chapters on different models of Parkinson's disease, Huntington's disease, and Alzheimer's disease complete the text.

Several of the models of Parkinson's disease are excellent and faithfully reproduce many important aspects of the disease. These models have proven to be extremely useful in studying approaches to treatment. On the other hand, the models of Huntington's disease, Alzheimer's disease, and motor neuron disease have much more limited use, reproduce only limited features of the

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