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March 1996

Brain Ischemia: Basic Concepts and Clinical Relevance

Author Affiliations

Iowa City, Iowa

Arch Neurol. 1996;53(3):222. doi:10.1001/archneur.1996.00550030024017

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This excellent, multiauthored book edited by Caplan spans the fields of basic knowledge on the pathophysiologic features of cerebrovascular disease and clinical stroke. The book is divided into seven sections: brain; eye; blood; blood vessels; blood flow, blood pressure and intracranial pressure; heart; and clinical research. Each section is buttressed by chapters at the beginning and end by Caplan. These brief statements introduce and summarize the most important information included in each section. Caplan's statements are excellent, and these alone are a reason to read this book.

Each section includes one to five chapters written by experts. These chapters are generally of very high quality. Particularly good are chapters on the mechanisms of cell death, endothelial cells and cerebrovascular disease, immunohematologic mechanisms of stroke, coagulation, and rheology. Conversely, the chapter on physical factors in the pathogenesis of atheroma formation was difficult to follow and understand.

Because of the large number

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