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May 1996

Cerebral and Extracerebral Abnormalities in Parkinson's Disease-Reply

Author Affiliations

Institute of Clinical Neurology University of Pisa Via Roma 67 56100 Pisa, Italy

Arch Neurol. 1996;53(5):402-403. doi:10.1001/archneur.1996.00550050024008

In reply  We appreciate the interest of Miaux in our article. He correctly observes that in the figures proton density—weighted and T2-weighted images are inverted because of a typing error.With regard to the second comment, we believe that the crescentic bilateral extracerebral hyperintensities with signal intensity different from that of cerebrospinal fluid, visible in the Figure 2 proton density—weighted image (top left), are adulterated areas caused by a chemical shift phenomenon1,2 from the lipidic component of the bone marrow. In fact, such hyperintensities are no longer visible either in the other published images (Figure 2, top right [T2-weighted image]; bottom right [sagittal proton density—weighted image], and left [sagittal T2—weighted image]) or in the other images of the same patient (Figure) not previously shown. Moreover, in all these images cerebrospinal fluid in the brain sulci is clearly visible and this discredits

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