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June 1996

Brain Development and Epilepsy

Author Affiliations

Charlottesville, Va

Arch Neurol. 1996;53(6):483. doi:10.1001/archneur.1996.00550060025009

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The concept that epilepsy in the developing brain is different from that in older children and adults goes back at least 100 years to the textbook, Diseases of Children, by Smith. The subsequent journey toward a better understanding of the developmental neurobiology of epilepsy is marked by a series of published milestones of which this volume is the latest and most detailed. The convergence of clinical epileptology, pediatric neurology, developmental neurobiology, and genetic molecular biology has resulted in a synthesis of these various approaches toward a better understanding of the basic nature of epileptogenesis, ictogenesis, and their interaction and dependence on various phases of brain development. The susceptibility to seizures in animals of various ages as expressed by individual functions, such as synaptic excitation and inhibition at the cellular and at the systemic levels of organization, is integrated with histogenetic migrational events and the development of excitability in developing neurons

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