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Article
July 1996

Proton Magnetic Resonance Spectroscopy of Vascular- and Alzheimer-Type Dementia

Author Affiliations

From the Departments of Neurology (Drs Kattapong and Rosenberg and Ms Wesley) and Psychiatry (Dr Kodituwakku) and Center for Non-Invasive Diagnosis (Dr Brooks), University of New Mexico School of Medicine, and the Neurology Service, Veterans Affairs Medical Center, Albuquerque, NM. Dr Kattapong is currently with the Department of Neurology, University of Vermont College of Medicine, Burlington.

Arch Neurol. 1996;53(7):678-680. doi:10.1001/archneur.1996.00550070116019
Abstract

Objective:  To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia.

Design and Subjects:  Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia.

Results:  The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P<.02).

Conclusion:  Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.

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