We have been following with much interest the articles in the Archives1,2 regarding posterior cortical atrophy because case 5 in the original report1 has been 1 of our clinic patients. This patient, who initially presented at age 54 years with visual complaints, recently died after a 13-year course of progressive dementia. Neuropathological examination has revealed the presence of Alzheimer disease with numerous senile plaques and neurofibrillary tangles involving the frontal, temporal, and parietal neocortex; the hippocampus; and the pyriform cortex. Although there were also numerous plaques involving the occipital cortex, only a few tangles were present in that region.
Our results are consistent with the neuropathological findings of Victoroff et al2 and other investigators who have studied cases of posterior cortical atrophy3,4 and suggest that Alzheimer disease should be considered as 1 of the primary causes in its differential diagnosis. With the caution that no occipital
Ala TA, Frey WH, Clark HB. Posterior Cortical Atrophy: Neuropathological Correlations. Arch Neurol. 1996;53(10):958. doi:10.1001/archneur.1996.00550100020006
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