We applaud the efforts of Rohr and coworkers1 who published a further contribution addressing the cause of stroke in young adults with a case-control study.2 The authors make reference only to history of hypertension and diabetes and current cigarette smoking though other modifiable or unmodifiable risk factors, such as diet, obesity, migraine, alcohol abuse, oral contraceptive use, hypercholesterolemia, and hypertriglyceridemia, might have been easily included in their analysis. Their data on history of hypertension and current cigarette smoking are consistent with our odds ratios ranging from 2.7 (95% confidence interval [CI], 0.9-8.1) to 3.6 (95% CI, 1.7-7.5) in the different hypertension categories and the 3.4 odds ratio (95% CI, 2.3-5.1) that we found for current smoking.2
Rohr and coworkers1 also found very high odds ratios for diabetes (22.9 in white men and 6.2 in white women, respectively), which were higher than expected. In fact, while the
Marini C, Carolei A. Traditional Risk Factors for Stroke in the Young. Arch Neurol. 1997;54(4):351–352. doi:10.1001/archneur.1997.00550160007004
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: