Investigators are beginning to reexamine the use of vitamin E for the treatment of amyotrophic lateral sclerosis. Vitamin E was isolated in the 1920s, and the results of animal studies led rapidly to clinical use. Regrettably, vitamin E did not ameliorate the progression of amyotrophic lateral sclerosis for Lou Gehrig, but more recent advances may identify subpopulations that do respond to vitamin E.
Reider CR, Paulson GW. Lou Gehrig and Amyotrophic Lateral SclerosisIs Vitamin E to Be Revisited?. Arch Neurol. 1997;54(5):527–528. doi:10.1001/archneur.1997.00550170013008