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October 1997

Headache Treatment Trial Methodology and New Drugs

Author Affiliations

Kansas City, Kan

Arch Neurol. 1997;54(10):1199-1200. doi:10.1001/archneur.1997.00550220015005

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This is a volume of 56 chapters, almost all of them quite brief. The first half of the volume relates to the methodological problems in clinical trials of drugs for the treatment of headache. The second half of the volume contains articles concerning effectiveness of sumatriptan, new methods of its administration, and reports of safety and efficacy of a variety of new 5-hydroxytriptamine 1D agonists in the treatment of migraine. The last section of the book is a potpourri of studies of other agents known to be useful, or considered as possibly useful, in the treatment of migraine—salicylates, substance P agonists, and sodium valproate.

There are several excellent aspects to this volume. The initial chapters enlighten the reader on the basics of clinical drug trials—the phases of research in new drugs and the problems of experimental design, such as decisions regarding the use of crossover vs parallel form studies. Several

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