Thank you for the opportunity to respond to Tyler's concerns regarding the results reported in our study.1 We stand by our article for the following reasons: (1) Changes between the published article and the first submission to the Journal of the Neurological Sciences were made in response to reviewers' concerns regarding controls; (2) we have always been conservative in the interpretation of data, and the change to a significant difference because of controls used for comparison did not alter our discussion of relevance to etiopathogenesis of epilepsy.
Tourtellotte WW, Sanders V. Serious Methodological Failures Concerning Presence of HSV DNA in Surgical Tissue From Human Epileptic Seizure Foci Detected by PCR—Reply. Arch Neurol. 1998;55(7):1032. doi:
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