We read with interest the article by Ghika and Bogousslavsky1 who found that 80% of their patients diagnosed as having progressive supranuclear palsy (PSP) had presymptomatic hypertension, suggesting that this might be a major feature in the diagnosis of PSP. However, we have not been able to confirm this finding in the setting of a multicenter case-control study of patients affected by PSP, designed to discern environmental and genetic factors possibly accounting for the pathogenesis of this disorder.2
Fabbrini G, Vanacore N, Bonifati V, Colosimo C, Meco G, for the Study Group on Atypical Parkinsonisms. Presymptomatic Hypertension in Progressive Supranuclear Palsy. Arch Neurol. 1998;55(8):1153–1154. doi:
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