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Letters to the Editor
December 1998

Limitations of Acetaminophen, Aspirin, and Caffeine in Alleviating Migraine

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Neurol. 1998;55(12):1590. doi:

The conclusions of Lipton et al1 that the combination of aspirin, acetaminophen, and caffeine was highly effective for the treatment of migraine headache symptoms requires further comment. They acknowledge in their "Patients and Methods" section that the most severely disabled segment of migraineurs was excluded. However, they do not tell us what percentage of the potential population was excluded for this reason. In a previous article2 by the first 2 authors of the current study, severe disability was identified in 50% of migraineurs who had been diagnosed by a physician and 25% of migraineurs who had not been previously diagnosed.