[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Controversies in Neurology
June 1999

Do We Have a Treatment for Alzheimer Disease?Yes

Author Affiliations

Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999

Arch Neurol. 1999;56(6):738-739. doi:10.1001/archneur.56.6.738

Since the acetylcholine deficit associated with Alzheimer disease (AD) was recognized in the mid-1970s, there has been a systematic attempt to increase central nervous system cholinergic activity by pharmacological manipulations. The main classes of drugs tested so far include acetylcholine precursors, releasing agents, cholinesterase inhibitors (CIs), and muscarinic agonists. The expectations were that cholinergic enhancement would improve symptoms of AD in a way similar to dopamine enhancement in Parkinson disease.