VLADIMIRHACHINSKIMD, FRCPC, DScMed
Since the acetylcholine deficit associated with Alzheimer disease (AD) was recognized in the mid-1970s, there has been a systematic attempt to increase central nervous system cholinergic activity by pharmacological manipulations. The main classes of drugs tested so far include acetylcholine precursors, releasing agents, cholinesterase inhibitors (CIs), and muscarinic agonists. The expectations were that cholinergic enhancement would improve symptoms of AD in a way similar to dopamine enhancement in Parkinson disease.
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