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Controversies in Neurology
June 1999

Do We Have a Treatment for Alzheimer Disease?Yes

Author Affiliations

From the McGill Centre for Studies in Aging, and Departments of Neurology and Neurosurgery, Psychiatry, and Medicine, McGill University, Montreal, Canada.



Arch Neurol. 1999;56(6):738-739. doi:10.1001/archneur.56.6.738

Since the acetylcholine deficit associated with Alzheimer disease (AD) was recognized in the mid-1970s, there has been a systematic attempt to increase central nervous system cholinergic activity by pharmacological manipulations. The main classes of drugs tested so far include acetylcholine precursors, releasing agents, cholinesterase inhibitors (CIs), and muscarinic agonists. The expectations were that cholinergic enhancement would improve symptoms of AD in a way similar to dopamine enhancement in Parkinson disease.

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