HACHINSKIVLADIMIRMD, FRCPC, DSc
ATHEROSCLEROSIS is the most common cause of coronary artery disease (CAD), peripheral vascular disease, and stroke worldwide. Atherogenesis is a multifactorial process involving cholesterol internalization, vascular smooth muscle cell proliferation, inflammation, "foam cell" formation, and connective tissue production.1Experimental and epidemiological studies of CAD, peripheral vascular disease, and stroke have identified powerful risk factors that directly affect these multifactorial processes and include hypertension, diabetes, smoking, and aging.2The relevance of cholesterol, however, has only been definitively associated with CAD and peripheral vascular disease, and has a seemingly tentative and controversial role with strokes.3,4For example, in the Framingham Study5no correlation was found between cholesterol and vascular disease of the brain. The Honolulu Heart Study6of Japanese American men showed no significant association with cerebral infarction but an inverse relationship with intracerebral hemorrhage. However, in the large Multiple Risk Factor Intervention Trial7of more than 350,000 men, death from nonhemorrhagic strokes correlated with elevated cholesterol, suggesting but not proving an association with atherothrombotic brain infarction (ABI). The Eastern Stroke and Coronary Heart Disease Collaborative Research Group study8of 69,767 participants revealed a trend toward a reduction in the risk of nonhemorrhagic stroke with decreasing cholesterol concentrations.
Demchuk AM, Hess DC, Brass LM, Yatsu FM. Is Cholesterol a Risk Factor for Stroke? Yes. Arch Neurol. 1999;56(12):1518–1520. doi:10.1001/archneur.56.12.1518
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: