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Controversies in Neurology
December 1999

Is Cholesterol a Risk Factor for Stroke?No

Author Affiliations

From the Department of Neurology, Washington University School of Medicine, St Louis, Mo.



Arch Neurol. 1999;56(12):1521-1524. doi:10.1001/archneur.56.12.1521

EASY, NO! But the counterquery is, Why bother? Answer: In the interest of our patients, we should be less incompetent concerning the pathogenesis and treatment of stroke. (Furthermore, NO also means nitric oxide; vide infra.) What's the rationale for our reasoning?

First let's parse and define the terms of the question. "Is," an intransitive verb, is the present tense of being now. "Cholesterol" is

the most abundant steroid in animal tissues, especially in bile and gall stones, and present in food, especially that rich in animal fats; circulates in the plasma complexed to proteins of various densities and [Stedman describes first structure and place, and now what must be presumed to be its major function] plays an important role in the pathogenesis of atheroma formation in arteries.1

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