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History of Neurology: Seminal Citation
February 2000

Wilson's Disease

Author Affiliations

Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

Arch Neurol. 2000;57(2):276-277. doi:10.1001/archneur.57.2.276

Wilson's disease, or hepatolenticular degeneration, is now known to result from defective biliary copper excretion with copper accumulation in several tissues, including the liver, brain, and cornea. An inevitably fatal disease at the time of Wilson's description, several treatment options are now available to control the disease manifestations. This article cites several seminal works published before the use of penicillamine in the treatment of Wilson's disease.1

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