Wilson's disease, or hepatolenticular degeneration, is now known to result from defective biliary copper excretion with copper accumulation in several tissues, including the liver, brain, and cornea. An inevitably fatal disease at the time of Wilson's description, several treatment options are now available to control the disease manifestations. This article cites several seminal works published before the use of penicillamine in the treatment of Wilson's disease.1
Robertson WM. Wilson's Disease. Arch Neurol. 2000;57(2):276–277. doi:10.1001/archneur.57.2.276
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