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History of Neurology: Seminal Citations
March 2000

Neurological Manifestations in Sjögren Syndrome

Author Affiliations

From the Service de Neurologie, Hôpital de la Salpêtrière, Paris, France.



Arch Neurol. 2000;57(3):411-413. doi:10.1001/archneur.57.3.411

Sjögren syndrome (SS) is a systemic autoimmune inflammatory disorder characterized by lymphocytic infiltration of exocrine glands with absent or diminished glandular secretion. The salivary and lacrimal glands are primarily involved, leading to dry eyes (xerophthalmia with keratoconjunctivitis sicca) and mouth (xerostomia). Cases of xerophthalmia and/or xerostomia were first mentioned in the late 19th and early 20th centuries. In 1933, studying these symptoms and their related manifestations, Sjögren,1 the Swedish ophthalmologist, concluded that they were manifestations of a general disease. Since then, the syndrome including xerophthalmia with keratoconjunctivitis and xerostomia bears Sjögren's name.

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