[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
History of Neurology: Seminal Citations
March 2000

Neurological Manifestations in Sjögren Syndrome

Author Affiliations

Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

Arch Neurol. 2000;57(3):411-413. doi:10.1001/archneur.57.3.411

Sjögren syndrome (SS) is a systemic autoimmune inflammatory disorder characterized by lymphocytic infiltration of exocrine glands with absent or diminished glandular secretion. The salivary and lacrimal glands are primarily involved, leading to dry eyes (xerophthalmia with keratoconjunctivitis sicca) and mouth (xerostomia). Cases of xerophthalmia and/or xerostomia were first mentioned in the late 19th and early 20th centuries. In 1933, studying these symptoms and their related manifestations, Sjögren,1 the Swedish ophthalmologist, concluded that they were manifestations of a general disease. Since then, the syndrome including xerophthalmia with keratoconjunctivitis and xerostomia bears Sjögren's name.