Manganese plays an important role as a cofactor in many enzymatic reactions in humans but in excess amounts can cause irreversible nervous system damage.1,2 Although manganism is a rare condition, it can be the cause of complex nervous system symptoms, especially in the setting of environmental exposure.3,4 Specifically, manganese is a well-known cause of dystonic parkinsonism.5 This article highlights several historical descriptions of the clinical manifestations, pathological changes, and attempted therapeutic intervention in manganese intoxication.
Lee J. Manganese Intoxication. Arch Neurol. 2000;57(4):597–599. doi:10.1001/archneur.57.4.597
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.