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Book Reviews
May 2000

Clinical Diagnosis and Management of Alzheimer's Disease, 2nd ed

Arch Neurol. 2000;57(5):756. doi:

Wide acceptance of a previous edition and significant advances in our understanding of specific topics are 2 requirements for a successful new edition of a scientific textbook. The second edition of Clinical Diagnosis and Management of Alzheimer's Disease clearly fulfills these 2 criteria. This textbook builds on the strength of the first edition, published in 1996. The basic structure of the textbook is unchanged. Original contributors together with a few additional contributors (a total of 54) review the basic science and clinical management of Alzheimer disease. The textbook is clearly written with practical aspects in mind. Several tables summarize major points in every chapter to orient the reader and also are useful for rapid overview. Two new chapters have been added. The chapter "Toward a Unifying Hypothesis of Alzheimer's Disease: Pathogenesis and Pathophysiology" is a thorough summary of recent progress in the molecular pathology of Alzheimer disease and is a useful resource for busy clinicians to learn about new developments in this area. Similarly, chapters describing neuroimaging have been separated into structural and functional chapters and include high-quality magnetic resonance images and positron emmission tomographic images. Recently concluded and ongoing drug trials and new trends in pharmacotherapy are reviewed in the chapter "Symptomatic Treatments for Alzheimer's Disease." Information about therapeutic approaches also is critically reviewed. This chapter is particularly useful for primary care physicians who care for patients with Alzheimer disease.

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