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Controversies in Neurology
April 2001

Inflammation After Stroke: Is It Harmful?

Author Affiliations

From the Department of Molecular and Experimental Medicine, The Scripps Research Institute, and the Division of Hematology/Medical Oncology, Scripps Clinic, La Jolla, Calif (Dr del Zoppo); the Department of Neurology, University of Washington, Harborview Medical Center, Seattle (Dr Becker); and the Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (Dr Hallenbeck).



Arch Neurol. 2001;58(4):669-672. doi:10.1001/archneur.58.4.669

TISSUE INJURY stimulates increased local blood flow and an influx of leukocytes to initiate wound repair. This response involves leukocyte adhesion receptors, the release of biologically active substances, and microvascular changes that allow the invasion by leukocytes. Inflammation plays a vital role in tissue recovery, serving an integral part of the host immune defense system. In patients with cerebral ischemia, however, the early inflammatory processes are likely to be deleterious.

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